BAZ

BAZ (bromodomain adjacent to zinc finger) family bromodomains are epigenetic reader domains that recognize acetylated lysine marks on histones and contribute to chromatin-based gene regulation through histone-acetylation-dependent protein recruitment^[1]^[2]. Within this family, BAZ2A and BAZ2B bromodomains bind acetylated histone tails, with evidence supporting preferential recognition of H3K14ac, a modification linked to chromatin remodeling and transcriptional control^[1]^[3]^[4]. Mechanistically, BAZ2A functions within chromatin regulatory complexes and mediates association with H3K14ac-enriched chromatin domains, thereby influencing transcriptional programs connected to cellular differentiation and developmental pathways^[3]^[5]. In disease-relevant models, BAZ2A bromodomain activity has been implicated in aggressive prostate cancer, where bromodomain-dependent chromatin engagement supports cancer stem-cell-like features and contributes to oncogenic transformation in PTEN-loss models^[5].

References:

[1]. Drouin L, et al. Structure enabled design of BAZ2-ICR, a chemical probe targeting the bromodomains of BAZ2A and BAZ2B. J Med Chem. 2015 Mar 12;58(5):2553-9. [Content Brief]

[2]. Moustakim M, et al. Chemical probes and inhibitors of bromodomains outside the BET family. Medchemcomm. 2016 Dec 7;7(12):2246-2264. [Content Brief]

[3]. Kiros M, et al. Trends in HIV-1 pretreatment drug resistance and HIV-1 variant dynamics among antiretroviral therapy-naive Ethiopians from 2003 to 2018: a pooled sequence analysis. Virol J. 2023 Oct 25;20(1):243. [Content Brief]

[4]. Gu X, et al. TE-TSS: an integrated data resource of human and mouse transposable element (TE)-derived transcription start site (TSS). Nucleic Acids Res. 2024 Jan 5;52(D1):D322-D333. [Content Brief]

[5]. Chen J, et al. Recent Progress and Prospect in Studying Selective Inhibitors Toward Bromodomain Family Members. Molecules. 2026 Mar 2;31(5):837. [Content Brief]

BAZ Inhibitor (1)

BAZ Related Products (1):

By Type:	Pan (1)

Cat. No.	Product Name	Effect	Purity

HY-77826

4-Chloro-N-methylpicolinamide	Inhibitor	99.89%
4-Chloro-N-methylpicolinamide (Compound 3) is a BAZ2A bromodomain inhibitor with a K_d of >500 μM. 4-Chloro-N-methylpicolinamide forms a weak hydrogen bond with the carbonyl oxygen of Pro1817. 4-Chloro-N-methylpicolinamide can be used in the research of invasive prostate cancer.

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